Synthesis and analgesic activity of 6-amino-2-piperazinylquinazolines
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Authors
Sambursky, S.E.
Kornylov, A. Yu.
Kabanova, T. A.
Khalimova, O. I.
Krysko, O. L.
Andronati, S. A.
Krysko, A. A.
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Abstract
6-Amino‑2-piperazinylquinazolin‑4-one and 2-piperazinyl‑4-phenylquinazoline derivatives
were synthesized. The analgesic activity of the obtained series of derivatives was investigated and it was found that the synthesized compounds showed high analgesic activity. ED50 values range from 0.46 to 0.88 mg/kg.
Description
Sambursky S.E. Synthesis and analgesic activity of 6-amino-2-piperazinylquinazolines / S.E. Sambursky, A. Yu. Kornylov, T.A. Kabanova, O.I. Khalimova, O.L. Krysko, S.A. Andronati, A.A. Krysko // Вісник ОНУ. Серія : Хімія. – 2021. – Т. 26, вип. 1 (77). – С. 74-84.
Citation
Sambursky S.E. Synthesis and analgesic activity of 6-amino-2-piperazinylquinazolines / S.E. Sambursky, A. Yu. Kornylov, T.A. Kabanova, O.I. Khalimova, O.L. Krysko, S.A. Andronati, A.A. Krysko // Вісник ОНУ. Серія : Хімія. – 2021. – Т. 26, вип. 1 (77). – С. 74-84.