Role of pCO2 (AV gap) of Multi Organ Dysfunction Syndrome

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dc.contributor.authorTarabrin, O.
dc.contributor.authorVasiliev, I.
dc.contributor.authorGroppa, S.
dc.contributor.authorGhicavii, V.
dc.contributor.authorD' Ambra, Mirta
dc.contributor.authorFriptu, V.
dc.contributor.authorGladun, S.
dc.contributor.authorDiug, V.
dc.contributor.authorSpinei, L.
dc.contributor.authorVartanov, V.
dc.contributor.authorStavrou, I.
dc.contributor.authorLitarczek, G.
dc.date.accessioned2023-04-25T11:56:36Z
dc.date.available2023-04-25T11:56:36Z
dc.date.issued2019
dc.descriptionVasiliev I. Role of pCO2 (AV gap) of Multi Organ Dysfunction Syndrome / I. Vasiliev, S. Groppa, V. Ghicavii, I. Stavrov, O. Tarabrin et al. // Journal of Biomedical and Pharmaceutical Sciences. - 2019. - Vol. 2, Issue 2. - P. 1–5.en_US
dc.description.abstractRecruitment of Microcirculatory-Mitochondrial (RMM) reduces Microcirculatory-Mitochondrial Distress Syndrome (MMDs), and Syndrome of Multi-Organ Dysfunction (MODs), by accelerated speed of delivery and return of blood flow which directly leads to a decrease in tissue hypoxia marker pCO2 (AV gap) and respectively with ↓ many other Endogenous Toxic Substances (ETS). In cases of pulmonary damage with ↑ pCO2 & ↓ Oxygenation Index PaO2 /FiO2 ↓ 300 the development of Acute Respiratory Distress Syndrome (ARDs), MMDs are also aggravated at ↑ with pCO2 AV gap. RMM also needs additional support of Multiple Organ Therapies-Multi-Organ Supportive Therapy (MOST), Alveolar Recruitment, Extracorporeal Life Support Organization (ELSO), Modeling of the Index of Extravascular Lung Fluid, EVLWI, Th4 - Th5 Thoracic Epidural Block, Active detoxification methods. The absence of decreasing of the pCO2 tissue hypoxia marker at the pCO2 AV gap ↓ 5.0 mmHg, after RMM proves the mitochondrial eu-energetic metabolic remodeling with the elimination of the hypo(an)ergic mitochondria performed by lysosomal clearance (mitophagy) makes the predominance eu-ergic mitochondria with the normalization of mitochondrial Ca++-uniporter-channel and mitochondrial permeability pore transition which productively inactivate the toxic forms of oxygen and nitrogen.en_US
dc.identifier.citationVasiliev I. Role of pCO2 (AV gap) of Multi Organ Dysfunction Syndrome / I. Vasiliev, S. Groppa, V. Ghicavii, I. Stavrov, O. Tarabrin et al. // Journal of Biomedical and Pharmaceutical Sciences. - 2019. - Vol. 2, Issue 2. - P. 1–5.en_US
dc.identifier.urihttps://hdl.handle.net/11300/24499
dc.language.isoenen_US
dc.subjectMicrocirculatory-Mitochondrial Distress Syndromeen_US
dc.subjectMicrocirculatory-Mitochondrial Recruitmenen_US
dc.subjectMultiple Organ Dysfunction Syndromeen_US
dc.subjectMarker of Tissue Hypoxia pCO2 (AV gap)en_US
dc.subjectAcute Respiratory Distress Syndromeen_US
dc.subjectMulti Organ Supportive Therapyen_US
dc.subjectMitochondral Remodelingen_US
dc.subjectMitochondrial Ca++ Uniporter Channelen_US
dc.subjectToxic forms of Oxygen and Nitrogenen_US
dc.subjectNascular Compliance ΔVPen_US
dc.titleRole of pCO2 (AV gap) of Multi Organ Dysfunction Syndromeen_US
dc.typeArticleen_US

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Тарабрін Олег Олександрович